Organic Chemistry-II Pharm-D – 2nd Semester

The 2nd semester of the Pharm-D program lays a strong foundation in both basic and pharmaceutical sciences, integrating theoretical and practical knowledge essential for future clinical practice.

Theory Subjects:

Pharmaceutical Chemistry IB (Organic Chemistry-II)

Course Learning Outcomes:
1. Describe the preparation, properties, and pharmaceutical relevance of key heterocyclic compounds and fused ring systems.
2. Explain mechanisms involving reactive intermediates and named organic reactions with applications in drug synthesis.
3. Apply advanced organic synthesis methods including green chemistry and microwave-assisted synthesis in pharmaceutical compound development.
4. Demonstrate laboratory proficiency in synthesizing pharmaceutically important compounds using classical and green organic methods.

Contents:
1. Heterocyclic Chemistry: Preparation and properties of medicinally important Heterocyclic Compounds such as pyrrole, furan, thiophene, pyridine, pyrimidine and pyrazine. Preparation and properties of heterocyclic compounds in which benzo-ring is fused with five and six membered rings containing one hetero atom; Indole, Quinoline and Isoquinoline. Additional Rings and Pharmaceuticals: imidazole (histamine, antifungals), purine/pyrimidine bases (DNA/RNA), benzoxazole, benzothiazole.
2. Reaction Mechanisms and Reactive Intermediates: An Overview of Reactive Intermediates: Carbocations, Carbanions, Carbenes, Nitrenes, Benzynes and Free Radicals and Free radical scavengers and their applications. Mechanism and applications of various reactions: Arndt-Eistert reaction, Baeyer-Villiger oxidation, Diels Alder reaction; Grignard’s reaction, Metal Hydride reduction and Wolff Kishner reduction, Friedel Craft’s reaction, Perkin reaction, Cannizzaro’s reaction, Mannich reaction, Pinacol-Pinacolone, Wagner-Meerwein, Wolff, Hofmann and Beckmann rearrangements, Condensation reaction (Aldol condensation, Favorskii rearrangement, Wittig rearrangement). Pericyclic and Photochemical Reactions.
3. Advanced Organic Chemistry: Brief introduction of Organic synthesis, Total Synthesis, Semi Synthesis Biocatalyst, Green Chemistry, Microwave assisted Synthesis