Biopharmaceutics & PK-II – 8th Semester

The 8th semester of the Pharm-D program lays a strong foundation in both basic and pharmaceutical sciences, integrating theoretical and practical knowledge essential for future clinical practice.

Theory Subjects:

Course Content:
1. Pharmacokinetics: Introduction, Linear and Non-linear Pharmacokinetics Application of pharmacokinetics in various situations. Pharmacokinetics and its related fields (Clinical Pharmacokinetics, population pharmacokinetics, Pharmacodynamics, Toxicokinetic, Clinical
toxicology, clinical pharmacology, forensic science, therapeutic drug monitoring, pharmacogenetics).
2. Biological Half Life and Volume of Distribution: Zero order and first order half-life, factors affecting and application of half-life. Apparent volume of distribution, concepts and factors affecting volume of distribution.
3. Pharmacokinetic modelling: Introduction and types of PK modelling, Compartment models, Non-compartmental approach, Concept and PK parameters after IV bolus single dose administration. Compartment models for extravascular administration of Drugs. Application of compartment models to determine various PK parameters of extra-vascularly administered drugs. Concepts of Wagner-Nelson Method, Flip-flop Phenomenon, Loo-Riegelman Method.
4. Multiple Dosage Regimen: Introduction, concept and PK parameters in Multiple dosing Pharmacokinetics after IV administration, Drug Accumulation and Principle of superposition.
5. Pharmacokinetics of Intravenous Infusions: Introduction and assessment of various parameters in Pharmacokinetics of IV infusion.
6. Pharmacokinetics Variations in Disease States: Determination of pharmacokinetics variations in renal and hepatic diseases, general approaches for dose adjustment in renal and hepatic diseases.
7. Pharmacokinetic and Pharmacodynamic (PK/PD) correlation.
8. Introduction to in-silico mechanistic modelling for physiologically based pharmacokinetic (PBPK)
and whole body PBPK.