Organic Chemistry- Doctor of Pharmacy – First Semester

The first semester of the Pharm.D program lays a strong foundation in both basic and pharmaceutical sciences, integrating theoretical and practical knowledge essential for future clinical practice.

Theory Subjects:

Pharmaceutics-I (Physical Pharmacy)

Course Learning Outcomes:
After completion of this course the students will be able to:
1. Understand organic chemistry concepts such as bonding, hybridization, and reactivity, with a
focus on pharmaceuticals.
2. Synthesize and characterize organic compounds for drug development, emphasizing
nomenclature and reaction mechanisms.
3. Analyze organic reactions like oxidation, reduction, and substitution, focusing on pharmaceutical
applications.
4. Apply green chemistry and synthesis methods to develop pharmaceutical compounds,
emphasizing sustainability.

Contents:
The following topics will be taught with special reference to their Pharmaceutical Applications.
1. Basic concepts: Chemical Bonding and concept of Hybridization, Conjugation, Resonance, Hyperconjugation, Aromaticity, Electronegativity, Dipole Moment, Inductive effect, Mesomeric Effect, Electrometric effect, Hydrogen bonding, Steric effect, and Tautomerism (keto-enol in
tetracyclines and lactam-lactim).
2. Synthesis, structure, nomenclature, properties, and pharmaceutical applications of functional organic compounds in drugs synthesis: Alkane, Alkenes, Alkynes, Alcohol, phenols, ethers, amines, Ketones, Aldehydes, Carboxylic Acids, Esters, Amides, Alkyl halide, and
Aromatic compounds.
3. Types of reactions in aliphatic and aromatic systems and their applications: Organic Reactions Mechanism: Oxidation, Reduction, Acylation, Esterification, and Nucleophilic Substitution reactions (SN1, SN2). Elimination Reactions, Addition Reactions, Rearrangement, and Polymerization Reactions.
4. Stereochemistry and Conformational Analysis: Stereoisomerism, Optical Isomerism; Molecules with more than one chiral center, Geometrical Isomerism, (cis/trans, E/Z system), Optical Isomerism including chirality and dextro/levo, R/S system. Resolution of racemic mixture, Conformational analysis (emphasizing Perspective formula and Fischer projection) and Applications in pharmacy.